SMYD3-IN-2

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SMYD3-IN-2

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

SMYD3-IN-2 是一种SMYD3抑制剂，可通过诱导致死性自噬来对抗胃癌。SMYD3-IN-2 对 SMYD3 和 BGC823 细胞具有抑制作用，IC₅₀值分别为 0.81 μM 和 0.75 μM。SMYD3-IN-2 可用于癌症的研究。

生物活性

SMYD3-IN-2 is aSMYD3inhibitor against gastriccancervia inducing lethalautophagy. SMYD3-IN-2 has inhibitory forSMYD3and BGC823 cells withIC₅₀values of 0.81 μM and 0.75 μM, respectively. SMYD3-IN-2 can be used for the research ofcancer^[1].

IC₅₀& Target

SMYD3

0.81 μM μM (IC₅₀)

体外研究
(In Vitro)

SMYD3-IN-2 (compound 7r) (1.0 μM) 对 SMYD3 和 BGC823 细胞表现出强效抑制能力，IC₅₀值分别为 0.81 μM和 0.75 μM^[1].
SMYD3-IN-2 (1.0 μM; 24 h) 可抑制 SMYD3 引起的 Akt 甲基化和激活^[1]。
SMYD3-IN-2 (0-48 h) 通过诱导自噬性细胞死亡抑制 BGC823 胃腺癌细胞的增殖^[1]。

Western Blot Analysis^[1]

Cell Line:	BGC823 cells
Concentration:	1.0 μM
Incubation Time:	24 h
Result:	Suppressed the methylation levels of H3K4 and could significantly inhibit the lysine methylation of Akt1 by SMYD3.

体内研究
(In Vivo)

SMYD3-IN-2 (compound 7r) (i.p.; 15 and 30 mg/kg) suppresses the growth of BGC823 xenograft models in vivo^[1].

Animal Model:	Xenograft Balb/c nude mice models^[1]
Dosage:	15 and 30 mg/kg
Administration:	Intraperitoneally administration
Result:	Remarkably suppressed the tumor volume, tumor weight and growth curves of gastric cancer xenografts in a dose-dependent manner. Resulted in strong immunohistochemistry staining of LC3-II and p62, weak staining of p-Akt (T308) and Ki67.

分子量

505.36

Formula

C₂₆H₂₁BrN₂O₄

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.