Venadaparib (IDX-1197) hydrochloride is a potent and selectivePARPinhibitor with anticancer activities. Venadaparib hydrochloride can be used for solid tumors research^[1][2].

Venadaparib (example 143; 6-10 days) shows potent growth inhibition of MDA-MB-436 cells and Capan-1 pancreatic cancer cells with IC₅₀values of ≤5nM and 50nM[2].

In the germline BRCA1-mutated ovarian cancer PDX model, oral administration of Venadaparib (IDX-1197) exhibits significant PAR inhibition (>90%) in tumor tissues until 24 hr post dose. Venadaparib also dose-dependently led to potent tumor growth inhibition compared to Olaparib treatment group^[1].

442.91

C₂₃H₂₄ClFN₄O₂

1681020-60-9

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.