Virodhamine

立即咨询

Virodhamine

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

287937-12-6

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
25mg	电议
50mg	电议
100mg	电议
200mg	电议
500mg	电议

产品介绍

Virodhamine 是一种内源性大麻素，它通过激活大麻素 (CB) 受体调节神经传递。Virodhamine 是CB1受体的拮抗剂和CB2受体的激动剂。Virodhamine 通过触发MAPK信号和ROS的产生诱导巨核细胞分化。 Virodhamine 可用于治疗各种神经疾病，如阿尔茨海默病和帕金森。

生物活性

Virodhamine is an endocannabinoid, it regulates neurotransmission by activating the cannabinoid (CB) receptors. Virodhamine is an antagonist ofCB1receptor and an agonist ofCB2receptor. Virodhamine induces megakaryocytic differentiation by triggeringMAPKsignaling andROSproduction. Virodhamine can be used for the research of various neurological disorders such as Alzheimer's and Parkinson's diseases^[1]^[2].

体外研究
(In Vitro)

Virodhamine (50 nM; 72 h) increases adherence, membrane expansion and the size of nucleus^[1].
Virodhamine (10-40 μM; 72 h) increases the expression level of CD61 and TRPV1^[1].
Virodhamine (72 h) inhibits the cell proliferation of megakaryocyte cells and significantly increases the portion of high ploidy cells as compared to control^[1].
Virodhamine significantly increases the protein expression level of CB2 receptorn, ROS production and NAPDH oxidase NOX4 expression in megakaryocytic cells^[1].

RT-PCR^[1]

Cell Line:	Megakaryocyte cell line
Concentration:	10, 20 and 40 μM
Incubation Time:	72 h
Result:	Dose‐dependently enhanced the expression level of megakaryocytic marker CD61 and the expression of TRPV1 mRNA.

体内研究
(In Vivo)

Virodhamine (1-10 mg/kg; i.p. once) repairs the nicotine (0.8 mg/kg) and immobilization stress induced anxiety in vivo^[2].

Animal Model:	Male ICR mice with nicotine (0.8 mg/kg) and immobilization stress induced anxiety^[2]
Dosage:	1, 5 and 10 mg/kg
Administration:	Intraperitoneal injection; 1-10 mg/kg; once
Result:	Significantly repaired the working memory impairment-like behaviors s at a does of 5 mg/kg and showed significant anxiolytic-like effects against the anxiety-like behaviors at a does of 10 mg/kg.

分子量

347.53

性状

Viscous liquid

Formula

C₂₂H₃₇NO₂

CAS 号

287937-12-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : ≥ 100 mg/mL(287.74 mM)

*"≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.8774 mL	14.3872 mL	28.7745 mL
5 mM	0.5755 mL	2.8774 mL	5.7549 mL
10 mM	0.2877 mL	1.4387 mL	2.8774 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。