CB1/2 agonist 3 (compound 52), a potent non-selective cannabinoid ligand, is aCB1/CB2(cannabinoid receptor) competitive agonist. CB1/2 agonist 3 acts on hCB1 and hCB2 with K_ivalues of 5.9 nM and 3.5 nM, respectively^[1].

CB1/2 agonist 3 (compound 52) can partially induce [³⁵S]GTPγS binding to hCB1-CHO cell membranes with an EC₅₀value of 30.99 nM, and slightly inhibit [³⁵S]GTPγS binding to hCB2-CHO cell membranes with a mean EC₅₀value of 1.28 nM^[1].
CB1/2 agonist 3 (compound 52) ((1 μM, 1 h) has antagonistic effect on CB1/CB2 agonist CP-55940 with a K_bvalue of 78.17 nM^[1].

387.60

C₂₅H₄₁NO₂

2772655-86-2

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