CB1/2 agonist 2

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CB1/2 agonist 2

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2772379-97-0

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

CB1/2 agonist 2 (compound 23) 是一种有效的非选择性大麻素 (cannabinoid) 配体，其K_i分别为 3.5 nM 和 1.2 nM。CB1/2 agonist 2 可以作为CB1的完全激动剂和CB2竞争性反向激动剂。CB1/2 agonist 2 具有抗伤害活性。

生物活性

CB1/2 agonist 2 (compound 23) is a potent non-selectivecannabinoidligand, withK_ivalues of 3.5 and 1.2 nM, respectively. CB1/2 agonist 2 can behave as a fullCB1agonist andCB2competitive inverse agonist. CB1/2 agonist 2 shows antinociceptive activity^[1].

IC₅₀& Target

hCB2-R

1.2 nM (Ki)

hCB1-R

3.5 nM (Ki)

体外研究
(In Vitro)

CB1/2 agonist 2 (compound 23) (1 μM, 24-72 h) exhibits a very low cytotoxic potential in Hep-G2 cells^[1].
CB1/2 agonist 2 (0-10 μM) shows a slight but significant inhibition of [35S]GTPγS binding to hCB2-CHO cell membranes, with a mean EC₅₀of 397.90 nM and a mean E_maxvalue of -17.81%^[1].

Cell Cytotoxicity Assay^[1]

Cell Line:	Human hepatoblastoma (Hep-G2) cells
Concentration:	1 μM
Incubation Time:	24, 48 or 72 h
Result:	Exhibited a very low cytotoxic potential, as Hep-G2 cell viability was comparable to controls after 24-72 h of treatment.

体内研究
(In Vivo)

CB1/2 agonist 2 (compound 23) (0-6 mg/kg, IP, once) significantly reduces the late phase of formalin-induced nocifensive behaviour at 6 mg/kg^[1].

Animal Model:	Male CD-1 outbred mice (40-45 g)^[1]
Dosage:	0, 1, 3, and 6 mg/kg
Administration:	IP, once, 10 min before the formalin or saline injection
Result:	Significantly reduced the late phase of formalin-induced nocifensive behaviour at the highest dose (6 mg/kg, i.p.), whereas no effect was produced by doses of 1 and 3 mg/kg.

分子量

417.62

Formula

C₂₆H₄₃NO₃

CAS 号

2772379-97-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.