COX-2-IN-27

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COX-2-IN-27

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2413565-17-8

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

COX-2-IN-27 是一种有效的选择性COX-2抑制剂，对 COX-1, COX-2, 15-LOX 的IC₅₀值分别为 13.22, 0.045, 1.67 μM。COX-2-IN-27 具有抗炎活性。

生物活性

COX-2-IN-27 is a potent and selectiveCOX-2inhibitor withIC₅₀values of 13.22, 0.045, 1.67 μM forCOX-1,COX-2,15-LOX, respectively. COX-2-IN-27 shows anti-inflammatory activity^[1].

IC₅₀& Target^[1]

COX-1

13.22 μM (IC₅₀)

COX-2

0.045 μM (IC₅₀)

15-LOX

1.67 μM (IC₅₀)

体外研究
(In Vitro)

COX-2-IN-27 (compound 15b) shows significant COX-2 selectivity with an SI value of 293.78^[1].

体内研究
(In Vivo)

COX-2-IN-27 (28 μM/kg) shows a potent anti-inflammatory activity in rats with edema inhibition relative to indomethacin of 93.20% and 109.08% in 4h and 3h, respectively^[1].

分子量

602.20

Formula

C₂₉H₂₄ClN₇S₃

CAS 号

2413565-17-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.