SERCA2a activator 1 (Compound A) is asarco/endoplasmic reticulum Ca²⁺-dependent ATPase 2a (SERCA2a)activator. SERCA2a activator 1 attenuates phospholamban inhibition and enhances the systolic and diastolic functions of the heart. SERCA2a activator 1 can be used for heart failure^[1].

SERCA2a^[1]

SERCA2a activator 1 (Compound A) activates the Ca²⁺-dependent ATPase activity of cardiac sarcoplasmic reticulum (SR) vesicles but not that of skeletal muscle SR vesicles that lack phospholamban (PLN). The surface plasmon resonance assay reveals a direct interaction between SERCA2a activator 1 and PLN, suggesting that the binding of SERCA2a activator 1 to PLN attenuates its inhibition of SERCA2a, resulting in SERCA2a activation^[1].
SERCA2a activator 1 also increases the Ca²⁺transients and contraction and relaxation of isolated adult rat cardiomyocytes. In isolated perfused rat hearts, the SERCA2a activator 1 enhances systolic and diastolic functions^[1].

SERCA2a activator 1 (Compound A; 30mg/kg; intravenous injection; male Wistar rats) treatment significantly enhances the diastolic function in anesthetized normal rats^[1].

551.66

Solid

C₃₂H₂₉N₃O₄S

2139330-34-8

Room temperature in continental US; may vary elsewhere.

DMSO : 62.5 mg/mL(113.29 mM;ultrasonic and warming and heat to 80℃)

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