环指蛋白105抗体

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环指蛋白105抗体


交货期:	1周
产品别名:	Anti-TTC3 Anti-tetratricopeptide repeat domain 3 Antibody

产品介绍

靶标：

TTC3

产品别名：

DCRR1； RNF105； TPRDIII； TTC3； tetratricopeptide repeat domain 3； tetratricopeptide repeat domain 3； E3 ubiquitin-protein ligase TTC3； RING finger protein 105； RING-type E3 ubiquitin transferase TTC3； TPR repeat protein 3； TPR repeat protein D； tetratricopeptide repeat protein 3；环指蛋白105；

背景信息：

E3 ubiquitin-protein ligase which catalyzes the formation of 'Lys-48'-polyubiquitin chains. Mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3 in the nucleus. Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation. Positively regulates TGFB1-induced epithelial-mesenchymal transition and myofibroblast differentiation by mediating the ubiquitination and subsequent degradation of SMURF2. Regulates neuronal differentiation by regulating actin remodeling and Golgi organization via a signaling cascade involving RHOA, CIT and ROCK. Inhibits cell proliferation.

宿主：Rbt
类型：Pab
同种型:IgG
应用：WB
纯化方式：亲和纯化
偶联物：Unconjugated
性状：液体
存储溶液：参阅说明书
浓度：Batch dependent (Please refer to the vial label for the specific concentration.)
稀释比例: Optimal dilutions/concentrations should be determined by the end user
储存：经常使用则4°C保存。-20°C保存不超过两年。避免反复冻融。
注意事项：仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。