产品介绍 基因名： MLLT6 产品别名： AF17； MLLT6； MLLT6, PHD finger containing； MLLT6, PHD finger containing； protein AF-17； ALL1-fused gene from chromosome 17 protein； KMT2A-MLLT6 fusion protein； KMT2A/MLLT6 fusion； MLLT6, PHD finger domain containing； MLLT6/KMT2A fusion； Myeloid/lymphoid or mixed-lineage leukemia, translocated to, 6； myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 6； myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6； myeloid/lymphoid or mixed-lineage leukemia; translocated to, 6； trithorax homolog； 髓细胞/淋巴细胞或混合谱系白血病蛋白6； 背景信息： The gene encoding the Mixed-Lineage Leukemia (MLL) proteins is located on chromosome 11q23. Chromosomal translocations involving band 11q23 result in rogue activator proteins that are associated with approximately 10% of patients with acute lymphoblastic leukemia (ALL) and 5% of patients with acute myeloid leukemia (AML). Most patients affected are less than 1 year of age. The gene encoding MLLT6, also known as mixed-lineage leukemia translocated to 6 or AF17, is located on chromosome 17q12 and encodes a 1093 amino acid protein that is thought to be involved in the translocations on chromosome 11q23. Localized to the nucleus, MLLT6 contains a leucine-zipper dimerization motif located 3-prime of the fusion point and a cysteine-rich domain at the C-terminus. MLLT6 is thought to play a role in ALL by repressing the activity of the truncated ALL1 protein. 标签：His-tag |
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