蛋白质/抗原/多肽 >> 重组蛋白
重组中断位点蛋白STIL
产品介绍 基因名: STIL 产品别名: MCPH7; SIL; STIL; STIL centriolar assembly protein; STIL centriolar assembly protein; SCL-interrupting locus protein; SCL/TAL1 interrupting locus; TAL-1-interrupting locus protein; 中断位点蛋白STIL; 背景信息: TAL1 disruption at 1p32, a common rearrangement in the T-cell acute lymphoblastic leukemia, usually results in the formation of a SCL interrupting locus (SIL)-TAL1 fusion product. SIL is an immediate early gene whose expression is associated with cell proliferation. The Sil protein exhibits ubiquitous expression in hematopoietic cell lines and tissues. However, Sil protein levels remain tightly regulated during the cell cycle, achieving peak levels in mitosis and diminishing on transition to G1 phase. Overexpression of Sil in primary adenocarcinomas predicts metastatic spread, especially in lung tumors with increased mitotic activity. 标签:His-tag |
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