蛋白质/抗原/多肽 >> 重组蛋白
重组锌指蛋白198
产品介绍 基因名: ZMYM2 产品别名: FIM; MYM; NECRC; RAMP; SCLL; ZNF198; ZMYM2; zinc finger MYM-type containing 2; zinc finger MYM-type containing 2; zinc finger MYM-type protein 2; fused in myeloproliferative disorders protein; rearranged in an atypical myeloproliferative disorder; zinc finger protein 198; zinc finger, MYM-type 2; 锌指蛋白198; 背景信息: Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZNF198 (zinc finger 198), also known as ZMYM2 (zinc finger, MYM-type 2), FIM, MYM, RAMP or SCLL, is a 1,377 amino acid protein that localizes to the nucleus and contains nine MYM-type zinc fingers. Thought to be a component of the BHC histone deacetylase complex, ZNF198 interacts with HDAC1 and HDAC2 and is thought to stabilize the BHC complex via its MYM-type zinc fingers. The gene encoding ZNF198 is subject to a translocation with Flg, an event that may be involved in the pathogenesis of stem cell leukemia lymphoma syndrome (SCLL), a lymphoblastic lymphoma often accompanied by pronounced peripheral eosinophilia and/or prominent eosinophilic infiltrates in the affected bone marrow. 标签:His-tag |
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