蛋白质/抗原/多肽 >> 重组蛋白
重组淋巴细胞抗原Ly6D蛋白
产品介绍 基因名: LY6D 产品别名: E48; Ly-6D; LY6D; lymphocyte antigen 6 family member D; lymphocyte antigen 6 family member D; lymphocyte antigen 6D; e48 antigen; lymphocyte antigen 6 complex, locus D; 淋巴细胞抗原Ly6D; 背景信息: Ly-6D is a 128 amino acid glycoprotein that is expressed in squamous cell carcinoma cell lines and squamous cell epithelia tissue. Ly-6D contains a signal peptide, 2 theoretical phosphorylation sites and 3 putative myristoylation sites. Upregulation of the gene encoding Ly-6D in head and neck cancers is associated with poor prognosis and high expression of Ly-6D has been linked to enhanced cell migration. Ly-6D is frequently used as a molecular marker for diagnosis and therapy of head-and-neck squamous cell carcinoma (HNSCC). It has been suggested that Ly-6D may regulate the expression levels of certain fucosylated E-selectin ligands and protein FX, a protein that contributes to the last step in the synthesis of GDP-L-fucose, in HNSCC cell lines. This finding is indicative that Ly-6D may regulate tumor cell adhesion in inflamed vessel walls that express E-selectin. 标签:His-tag |
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