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蛋白质/抗原/多肽 >> 重组蛋白
重组发育和分化增强因子PAG3蛋白
重组发育和分化增强因子PAG3蛋白图片
交货期: 1周
索取资料及报价
交货期:1周
产品别名:Recombinant ASAP2
Recombinant ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 protein
产品介绍
基因名:

ASAP2


产品别名:

AMAP2; CENTB3; DDEF2; PAG3; PAP; Pap-alpha; SHAG1; ASAP2; ArfGAP with SH3 domain, ankyrin repeat and PH domain 2; ArfGAP with SH3 domain, ankyrin repeat and PH domain 2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2; PYK2 C terminus-associated protein; centaurin, beta 3; development and differentiation-enhancing factor 2; paxillin-associated protein with ARF GAP activity 3; pyk2 C-terminus-associated protein; 发育和分化增强因子PAG3;


背景信息:
This gene encodes a multidomain protein containing an N-terminal alpha-helical region with a coiled-coil motif, followed by a pleckstrin homology (PH) domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-terminal Src homology 3 (SH3) domain. The protein localizes in the Golgi apparatus and at the plasma membrane, where it colocalizes with protein tyrosine kinase 2-beta (PYK2). The encoded protein forms a stable complex with PYK2 in vivo. This interaction appears to be mediated by binding of its SH3 domain to the C-terminal proline-rich domain of PYK2. The encoded protein is tyrosine phosphorylated by activated PYK2. It has catalytic activity for class I and II ArfGAPs in vitro, and can bind the class III Arf ARF6 without immediate GAP activity. The encoded protein is believed to function as an ARF GAP that controls ARF-mediated vesicle budding when recruited to Golgi membranes. In addition, it functions as a substrate and downstream target for PYK2 and SRC, a pathway that may be involved in the regulation of vesicular transport. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

标签:His-tag   
分类:Recombinant  
类型:Protein   
偶联物:Unconjugated
内毒素水平:按批次,参阅瓶身标签
性状:Liquid
浓度:Batch dependent (Please refer to the vial label for the specific concentration.)
纯化类型:purified
内含物:不含防腐剂
应用:Positive Control;Immunogen;SDS-PAGE;WB.
储存:2-8°C不超过一个月,-80°C不超过12个月。避免反复冻融。
注意事项:仅供实验室使用。不适用于人类或动物的任何临床,治疗或诊断用途。不适合动物或人类食用。

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