蛋白质/抗原/多肽 >> 重组蛋白
重组GTF3C5蛋白
产品介绍 基因名: GTF3C5 产品别名: TFIIIC63; TFIIICepsilon; TFiiiC2-63; GTF3C5; general transcription factor IIIC subunit 5; general transcription factor IIIC subunit 5; general transcription factor 3C polypeptide 5; TF3C-epsilon; TFIIIC 63 kDa subunit; general transcription factor IIIC, polypeptide 5, 63kDa; transcription factor IIIC 63 kDa subunit; transcription factor IIIC subunit epsilon; transcription factor IIIC, 63 kD; 背景信息: RNA polymerase (pol) III synthesizes tRNA, 5s rRNA, 7SL RNA and U6 snRNA and is overexpressed in many transformed cell lines and tumors in vivo, since cells must duplicate its protein components before division. Therefore, in order to maintain rapid growth, cells must produce a high level of Pol III transcribed RNA, which requires the presence of the TFIIIB and TFIIIC2 transcription factor complexes. The TFIIIC2 complex is composed of five subunits, TFIIIC220, TFIIIC110, TFIIIC102, TFIIIC90 and TFIIIC63, that are overexpressed in adenovirus transformed cells as well as in malignant cells in vivo, such as ovarian carcinomas. TFIIIC2 recruits RNA pol III and TFIIIB to promoter elements and may be a key component in the deregulation of malignant cells. The TFIIIB complex includes the TATA-binding protein (TBP), TFIIB-related factor 1 (BRF1) and TFIIIB’’, the expression of which are also upregulated in transformed cells. In many carcinomas, the tumor suppressors retinoblastoma (RB) and p53 are inactivated, which affects their ability to bind and inactivate the function of TFIIIB. 标签:His-tag |
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