蛋白质/抗原/多肽 >> 重组蛋白
重组含脯氨酸突触相关蛋白1
产品介绍 基因名: LZTS3 产品别名: PROSAPIP1; LZTS3; leucine zipper tumor suppressor family member 3; leucine zipper tumor suppressor family member 3; leucine zipper putative tumor suppressor 3; ProSAP/Shank-interacting protein 1; leucine zipper, putative tumor suppressor family member 3; proline rich synapse associated protein interacting protein 1; 含脯氨酸突触相关蛋白1; 背景信息: The ProSAP family of proteins contain many protein-protein interaction domains and serve as scaffolding mediators within the post-synaptic density (PSD) of excitatory brain synapses. The PSD is an electron-dense structure underneath the post-synaptic plasma membrane of excitatory synapses that anchors and clusters glutamate receptors opposite to the pre-synaptic neurotransmitter release site. Shank proteins contain PDZ modular domains that coordinate the synaptic localization of ion channels, receptors, signaling enzymes, and cell adhesion molecules. The PDZ domain mediates protein-protein interactions via the recognition of a conserved sequence motif at the C-terminus of their target protein(s). ProSAPiP1 (proline rich synapse associated protein interacting protein 1) is a 673 amino acid protein that interacts with the PDZ domain of Shank 3. ProSAPiP1 expression is brain-specific with highest expression within the cerebellum, hippocampus and cerebral cortex. 标签:His-tag |
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