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蛋白质/抗原/多肽 >> 重组蛋白
重组ARF鸟苷酸交换因子BIG1蛋白
重组ARF鸟苷酸交换因子BIG1蛋白图片
交货期: 1周
索取资料及报价
交货期:1周
产品别名:Recombinant ARFGEF1
Recombinant ADP ribosylation factor guanine nucleotide exchange factor 1 protein
产品介绍
基因名:

ARFGEF1


产品别名:

ARFGEP1; BIG1; P200; ARFGEF1; ADP ribosylation factor guanine nucleotide exchange factor 1; ADP ribosylation factor guanine nucleotide exchange factor 1; brefeldin A-inhibited guanine nucleotide-exchange protein 1; ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited); p200 ARF guanine nucleotide exchange factor; ARF鸟苷酸交换因子BIG1;


背景信息:
Guanine nucleotide-exchange proteins (GEPs) accelerate replacement of bound GDP with GTP and thereby activate ADP-ribosylation factors (ARFs), a family of guanine nucleotide-binding proteins that play an important role in intracellular vesicular trafficking. GEPs comprise two major families, large GEPs that are inhibited by brefeldin A (BFA), a protein that effects Golgi structure and a group of smaller GEPs that are insenstive to BFA. Two genes for GEPs found on human chromosomes 8 and 20 encode BFA sensitive GEPs designated BIG1 and BIG2. Both GEPS contain a sec7 domain that is responsible for their brefeldin inhibition and also their catalytic activity. In vivo, BIG1 and BIG2 exist in macromolecular complexes that move between the Golgi membranes and cytosol. BIG2 associates with PKA regulatory subunits, implying that BIG2 may act as an A kinase-anchoring protein (AKAP) that could coordinate the cAMP and ARF regulatory pathways.

标签:His-tag   
分类:Recombinant  
类型:Protein   
偶联物:Unconjugated
内毒素水平:按批次,参阅瓶身标签
性状:Liquid
浓度:Batch dependent (Please refer to the vial label for the specific concentration.)
纯化类型:purified
内含物:不含防腐剂
应用:Positive Control;Immunogen;SDS-PAGE;WB.
储存:2-8°C不超过一个月,-80°C不超过12个月。避免反复冻融。
注意事项:仅供实验室使用。不适用于人类或动物的任何临床,治疗或诊断用途。不适合动物或人类食用。

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