蛋白质/抗原/多肽 >> 重组蛋白
重组ARF鸟苷酸交换因子BIG1蛋白
产品介绍 基因名: ARFGEF1 产品别名: ARFGEP1; BIG1; P200; ARFGEF1; ADP ribosylation factor guanine nucleotide exchange factor 1; ADP ribosylation factor guanine nucleotide exchange factor 1; brefeldin A-inhibited guanine nucleotide-exchange protein 1; ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited); p200 ARF guanine nucleotide exchange factor; ARF鸟苷酸交换因子BIG1; 背景信息: Guanine nucleotide-exchange proteins (GEPs) accelerate replacement of bound GDP with GTP and thereby activate ADP-ribosylation factors (ARFs), a family of guanine nucleotide-binding proteins that play an important role in intracellular vesicular trafficking. GEPs comprise two major families, large GEPs that are inhibited by brefeldin A (BFA), a protein that effects Golgi structure and a group of smaller GEPs that are insenstive to BFA. Two genes for GEPs found on human chromosomes 8 and 20 encode BFA sensitive GEPs designated BIG1 and BIG2. Both GEPS contain a sec7 domain that is responsible for their brefeldin inhibition and also their catalytic activity. In vivo, BIG1 and BIG2 exist in macromolecular complexes that move between the Golgi membranes and cytosol. BIG2 associates with PKA regulatory subunits, implying that BIG2 may act as an A kinase-anchoring protein (AKAP) that could coordinate the cAMP and ARF regulatory pathways. 标签:His-tag |
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