产品介绍 基因名： GALNT6 产品别名： GALNAC-T6； GalNAcT6； GALNT6； polypeptide N-acetylgalactosaminyltransferase 6； polypeptide N-acetylgalactosaminyltransferase 6； polypeptide N-acetylgalactosaminyltransferase 6； GalNAc transferase 6； UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 6； UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 6； UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)； polypeptide GalNAc transferase 6； pp-GaNTase 6； protein-UDP acetylgalactosaminyltransferase 6； GalNAc-T6蛋白； 背景信息： This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. The encoded protein is capable of glycosylating fibronectin peptide in vitro and is expressed in a fibroblast cell line, indicating that it may be involved in the synthesis of oncofetal fibronectin. [provided by RefSeq, Jul 2008] 标签：His-tag |
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