蛋白质/抗原/多肽 >> 重组蛋白
重组UBX结构域域蛋白D2
产品介绍 基因名: UBXN4 产品别名: UBXD2; UBXDC1; erasin; UBXN4; UBX domain protein 4; UBX domain protein 4; UBX domain-containing protein 4; UBX domain containing 2; UBX domain-containing 1; UBX domain-containing protein 2; UBX结构域域蛋白D2; 背景信息: Erasin is an endoplasmic reticulum (ER) and nuclear envelope membrane protein. Expressed in a variety of tissues, such as brain, placenta, heart, liver, prostate, kidney, pancreas, lung and skeletal muscle, erasin contains one UBX domain and participates in the clearing of ERAD (endoplasmic reticulum-associated protein degradation) substrates. The UBX domain of erasin is responsible for mediating its direct interaction with VCP (valosin-containing protein), an AAA-ATPase molecular chaperone. In response to ER stress, erasin expression is induced. The knockdown of erasin expression leads to the inhibition of ERAD, suggesting an important function of erasin in the ERAD pathway. In addition, erasin may be involved in Alzheimer’s disease, as it is known to accumulate in neurofibrillary degenerating neurons in patients with Alzheimer’s disease. 标签:His-tag |
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