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蛋白质/抗原/多肽 >> 重组蛋白
重组UBX结构域域蛋白D2
重组UBX结构域域蛋白D2图片
交货期: 1周
索取资料及报价
交货期:1周
产品别名:Recombinant UBXN4
Recombinant UBX domain protein 4 protein
产品介绍
基因名:

UBXN4


产品别名:

UBXD2; UBXDC1; erasin; UBXN4; UBX domain protein 4; UBX domain protein 4; UBX domain-containing protein 4; UBX domain containing 2; UBX domain-containing 1; UBX domain-containing protein 2; UBX结构域域蛋白D2;


背景信息:
Erasin is an endoplasmic reticulum (ER) and nuclear envelope membrane protein. Expressed in a variety of tissues, such as brain, placenta, heart, liver, prostate, kidney, pancreas, lung and skeletal muscle, erasin contains one UBX domain and participates in the clearing of ERAD (endoplasmic reticulum-associated protein degradation) substrates. The UBX domain of erasin is responsible for mediating its direct interaction with VCP (valosin-containing protein), an AAA-ATPase molecular chaperone. In response to ER stress, erasin expression is induced. The knockdown of erasin expression leads to the inhibition of ERAD, suggesting an important function of erasin in the ERAD pathway. In addition, erasin may be involved in Alzheimer’s disease, as it is known to accumulate in neurofibrillary degenerating neurons in patients with Alzheimer’s disease.

标签:His-tag   
分类:Recombinant  
类型:Protein   
偶联物:Unconjugated
内毒素水平:按批次,参阅瓶身标签
性状:Liquid
浓度:Batch dependent (Please refer to the vial label for the specific concentration.)
纯化类型:purified
内含物:不含防腐剂
应用:Positive Control;Immunogen;SDS-PAGE;WB.
储存:2-8°C不超过一个月,-80°C不超过12个月。避免反复冻融。
注意事项:仅供实验室使用。不适用于人类或动物的任何临床,治疗或诊断用途。不适合动物或人类食用。

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