蛋白质/抗原/多肽 >> 重组蛋白
重组减数分裂蛋白SPO11
产品介绍 基因名: SPO11 产品别名: CT35; SPATA43; TOPOVIA; TOPVIA; SPO11; SPO11 initiator of meiotic double stranded breaks; SPO11 initiator of meiotic double stranded breaks; meiotic recombination protein SPO11; SPO11 meiotic protein covalently bound to DSB homolog; cancer/testis antigen 35; spermatogenesis associated 43; 减数分裂蛋白SPO11; 背景信息: Spo11 is a type II topoisomerase that is thought to generate the chromosome breaks that initiate meiotic recombination. The Spo11 protein initiates meiotic recombination by generating DNA double-strand breaks (DSBs) and is required for meiotic synapsis in S. cerevisiae. The DSBs are located mostly in promoter regions, where the chromatin is in an open configuration, and cluster in domains along the chromosome. Expression of the Spo11 is detected mainly in the testis, in agreement with its predicted function in the initiation of meiotic recombination. Disruption of Spo11 leads to severe gonadal abnormalities from defective meiosis and results in infertility. 标签:His-tag |
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