产品介绍 基因名: SIT1 产品别名: SIT; SIT-R; SIT1; signaling threshold regulating transmembrane adaptor 1; signaling threshold regulating transmembrane adaptor 1; signaling threshold-regulating transmembrane adapter 1; SHP-2 interacting transmembrane adaptor protein; SHP2 interacting transmembrane adaptor; SHP2-interacting transmembrane adapter protein; SHP2-interacting transmembrane adaptor protein; gp30/40; suppression inducing transmembrane adaptor 1; suppression-inducing transmembrane adapter 1; 信号阈值调节跨膜衔接因子1(SIT1); 信号阈值调节跨膜衔接因子1(SIT1)真核蛋白; 跨膜接头蛋白SIT; 背景信息: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012] 标签:His-tag |
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