蛋白质/抗原/多肽 >> 重组蛋白
重组NAGPA蛋白
产品介绍 基因名: Nagpa 产品别名: AI596180; UCE; Nagpa; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase; alpha-GlcNAcase; mannose 6-phosphate-uncovering enzyme; phosphodiester alpha-GlcNAcase; NAGPA蛋白; 背景信息: Hydrolases are transported to lysosomes after binding to mannose 6-phosphate receptors in the trans-Golgi network. This gene encodes the enzyme that catalyzes the second step in the formation of the mannose 6-phosphate recognition marker on lysosomal hydrolases. Commonly known as 'uncovering enzyme' or UCE, this enzyme removes N-acetyl-D-glucosamine (GlcNAc) residues from GlcNAc-alpha-P-mannose moieties and thereby produces the recognition marker. This reaction most likely occurs in the trans-Golgi network. This enzyme functions as a homotetramer of two disulfide-linked homodimers. In addition to having an N-terminal signal peptide, the protein's C-terminus contains multiple signals for trafficking it between lysosomes, the plasma membrane, and trans-Golgi network. [provided by RefSeq, Jul 2008] 标签:His-tag |
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