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蛋白质/抗原/多肽 >> 重组蛋白
重组胶质瘤抑癌候选基因2蛋白
重组胶质瘤抑癌候选基因2蛋白图片
交货期: 1周
索取资料及报价
交货期:1周
产品别名:Recombinant NOP53
Recombinant NOP53 ribosome biogenesis factor protein
产品介绍
基因名:

NOP53


产品别名:

GLTSCR2; PICT-1; PICT1; NOP53; NOP53 ribosome biogenesis factor; NOP53 ribosome biogenesis factor; ribosome biogenesis protein NOP53; glioma tumor suppressor candidate region gene 2 protein; p60; protein interacting with carboxyl terminus 1; 胶质瘤抑癌候选基因2;


背景信息:
The tumor suppressor PTEN plays an essential role in regulating signaling pathways involved in cell growth and apoptosis and is inactivated in a wide variety of tumors. Protein interacting with PTEN carboxyl terminus 1 (PICT-1), also designated p60 or Glioma tumor suppressor candidate region gene 2 protein, binds to the C-terminus of PTEN and regulates its turnover. Five Ser/Thr residues within the C-terminal segment of PTEN, including Ser-380, are phosphorylated upon binding of PTEN to PICT-1 and may contribute to the stabilization of PTEN. PICT-1 is localized to the nucleus and/or nucleolus and is highly expressed in pancreas and heart, but can also be detected in liver, skeletal muscle, placenta and kidney. PICT-1 also interacts with herpes simplex virus 1 regulatory proteins ICP22 and ICP0. The tumor suppressor GLTSCR2 gene, which encodes PICT-1, is located in a 150-kb minimal common deletion region for human gliomas, especially oligodendrogliomas, and maps to human chromosome 19q13.3.

标签:His-tag   
分类:Recombinant  
类型:Protein   
偶联物:Unconjugated
内毒素水平:按批次,参阅瓶身标签
性状:Liquid
浓度:Batch dependent (Please refer to the vial label for the specific concentration.)
纯化类型:purified
内含物:不含防腐剂
应用:Positive Control;Immunogen;SDS-PAGE;WB.
储存:2-8°C不超过一个月,-80°C不超过12个月。避免反复冻融。
注意事项:仅供实验室使用。不适用于人类或动物的任何临床,治疗或诊断用途。不适合动物或人类食用。

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