蛋白质/抗原/多肽 >> 重组蛋白
重组脱氧核糖磷酸醛缩酶样蛋白
产品介绍 基因名: Dera 产品别名: CG8525; Dmel\CG8525; Dera; Deoxyribose-phosphate aldolase; Deoxyribose-phosphate aldolase; Deoxyribose-phosphate aldolase; CG8525-PA; CG8525-PD; Dera-PA; Dera-PD; 脱氧核糖磷酸醛缩酶样; 背景信息: DERA is a 318 amino acid member of the deoC/fbaB aldolase protein family. Involved in the carbohydrate degradation pathway, DERA catalyzes the conversion of 2-deoxy-D-ribose 5-phosphate to D-glyceraldehyde 3-phosphate and an acetyldehyde. The gene that encodes DERA maps to human chromosome 12, which encodes over 1,100 genes within 132 million bases, making up about 4.5% of the human genome. A number of skeletal deformities are linked to chromosome 12, including hypochondrogenesis, achondrogenesis and Kniest dysplasia. Noonan syndrome, which includes heart and facial developmental defects among the primary symptoms, is caused by a mutant form of PTPN11 gene product, SH-PTP2. Chromosome 12 is also home to a homeobox gene cluster, which encodes crucial transcription factors for morphogenesis, and the natural killer complex gene cluster encoding C-type lectin proteins which mediate the NK cell response to MHC I interaction. Trisomy 12p leads to facial development defects, seizure disorders and a host of other symptoms varying in severity depending on the extent of mosaicism and is most severe in cases of complete trisomy. 标签:His-tag |
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