蛋白质/抗原/多肽 >> 重组蛋白
重组轴索过度生长抑制因子B受体蛋白
产品介绍 基因名: Nus1 产品别名: 1600027K07Rik; AU019165; AW538011; BC003223; D10Ertd438e; Nus1; NUS1 dehydrodolichyl diphosphate synthase subunit; NUS1 dehydrodolichyl diphosphate synthase subunit; dehydrodolichyl diphosphate synthase complex subunit Nus1; Nogo-B receptor; dehydrodolichyl diphosphate syntase complex subunit Nus1; di-trans,poly-cis-decaprenylcistransferase; ngBR; nuclear undecaprenyl pyrophosphate synthase 1 homolog; 轴索过度生长抑制因子B受体; 背景信息: Nogo is an oligodendrocyte-specific member of the Reticulon family and is a component of CNS white matter that inhibits axon outgrowth, induces collapse of growth cones of chick dorsal root ganglion cells, and inhibits the spreading of 3T3 fibroblasts. Nogo is expressed by oligodendrocytes but not by Schwann cells and associates primarily with the endoplasmic reticulum. Nogo exists in three different splice forms, Nogo-A, -B and -C. NgBR (Nogo-B receptor), also known as nuclear undecaprenyl pyrophosphate synthase 1 homolog, is a 293 amino acid single-pass type I membrane protein that acts as a specific receptor for the amino-terminus of Nogo-B. Through this interaction, NgBR is involved in the regulation of vascular remodeling and angiogenesis. NgBR also enhances Niemann-Pick type C2 protein (NPC2) stabilization. Knockdown of NgBR mRNA leads to decreased NPC2 levels, which results in the hallmarks of NPC2 mutation: increased intracellular cholesterol accumulation and a loss of sterol sensing. 标签:His-tag |
相关产品
|