蛋白质/抗原/多肽 >> 重组蛋白
重组MaFF相关蛋白
产品介绍 基因名: MIS18A 产品别名: B28; C21orf45; C21orf46; FASP1; MIS18alpha; hMis18alpha; MIS18A; MIS18 kinetochore protein A; MIS18 kinetochore protein A; protein Mis18-alpha; FAPP1-associated protein 1; MIS18 kinetochore protein homolog A; MaFF相关蛋白; 背景信息: Mapping to chromosome 21, the FASP1 gene (FAPP1-associated protein 1) encodes a 233 amino acid protein that is homologous to the fission yeast protein Mis18. In yeast, Mis18 is localized to the centrosome and forms a complex with Mis16 to maintain the deacetylated state of histones specifically in the central core of centromeres. FASP1, also known as Protein Mis18-alpha and C21orf45, is required for the recruitment of CENP-A to centrosomes and is thereby essential for normal chromosome segregation during mitosis. With expression in testis, FASP1 exists as a homodimer, a heterodimer with MIS18B or is present in a complex containing other Mis18 family members. FASP1 has been shown to bind to pp5644 in Hela cells, where overexpression of pp5644 leads to inhibited growth and colony formation. 标签:His-tag |
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