蛋白质/抗原/多肽 >> 重组蛋白
重组乳腺癌和卵巢癌易感基因RAD51C蛋白
产品介绍 基因名: TDRD1 产品别名: CT41.1; TDRD1; tudor domain containing 1; tudor domain containing 1; tudor domain-containing protein 1; cancer/testis antigen 41.1; testicular tissue protein Li 193; 乳腺癌和卵巢癌易感基因RAD51C; 背景信息: Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. The RAD51B-RAD51C dimer exhibits single-stranded DNA-dependent ATPase activity. The BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Participates in branch migration and Holliday junction resolution and thus is important for processing HR intermediates late in the DNA repair process. Also has an early function in DNA repair in facilitating phosphorylation of the checkpoint kinase CHK2 and thereby transduction of the damage signal, leading to cell cycle arrest and HR activation. Protects RAD51 from ubiquitin-mediated degradation that is enhanced following DNA damage. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and XRCC3. Contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability. Involved in maintaining centrosome number in mitosis. 标签:His-tag |
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