蛋白质/抗原/多肽 >> 重组蛋白
重组1号染色体开放阅读框85蛋白
产品介绍 基因名: Glmp 产品别名: 0610031J06Rik; AB027141; NCU-G1; Glmp; glycosylated lysosomal membrane protein; glycosylated lysosomal membrane protein; glycosylated lysosomal membrane protein; lysosomal protein NCU-G1; 1号染色体开放阅读框85; 糖化溶酶体膜蛋白(GLMP); 背景信息: C1orf85, also known as Lysosomal protein NCU-G1, is a 406 amino acid single-pass membrane protein that is highly glycosylated on its amino-terminal end. Transcription of the gene encoding C1orf85 is activated by TFEB, a transcription factor that specifically recognizes and binds E-box sequences. There are two isoforms of C1orf85 that are produced as a result of alternative splicing events. The C1orf85 maps to human chromosome 1, the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. 标签:His-tag |
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