产品介绍 基因名: MARCHF4 产品别名: MARCH-IV; MARCH4; RNF174; MARCHF4; membrane associated ring-CH-type finger 4; membrane associated ring-CH-type finger 4; E3 ubiquitin-protein ligase MARCHF4; E3 ubiquitin-protein ligase MARCH4; RING finger protein 174; RING-type E3 ubiquitin transferase MARCH4; RING-type E3 ubiquitin transferase MARCHF4; membrane associated ring finger 4; membrane-associated RING finger protein 4; membrane-associated RING-CH protein IV; membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase; 膜相关环指蛋白4; 背景信息: MARCH4, an E3 ubiquitin protein ligase, may mediate ubiquitination of MHC I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin protein ligases accept ubiquitin from an E2 ubiquitin conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. 标签:His-tag |
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