蛋白质/抗原/多肽 >> 重组蛋白
重组连接介导调节蛋白
产品介绍 基因名: Jmy 产品别名: Jmy; junction-mediating and regulatory protein; junction-mediating and regulatory protein; junction-mediating and -regulatory protein; p300 transcriptional cofactor JMY; 连接介导调节蛋白; 背景信息: Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location. 标签:His-tag |
相关产品
|