蛋白质/抗原/多肽 >> 重组蛋白
重组肥大细胞膜抑制性受体Allergin1蛋白
产品介绍 基因名: Milr1 产品别名: Mca32; Milr1; mast cell immunoglobulin-like receptor 1; mast cell immunoglobulin-like receptor 1; allergin-1; MCA-32; allergy inhibitory receptor 1; mast cell Ag-32; mast cell antigen 32; surface protein MCA-32; 肥大细胞膜抑制性受体Allergin1; 背景信息: As a major event in type Ⅰ allergic reaction,degranulation of mast cells is triggered by the interaction between specific IgEs and high affinity IgE receptors (FcεRIs) on mast cell membrane,and is followed by the release of a battery of inflammatory mediators,such as histamine,leukotrienes and arachidonic acid,and these inflammatory mediators in turn induce a series of allergic symptoms.Recently,Allergin-1 has been found to be an immunoglobulin-like receptor preferentially expressed on mast cells.The crosslinking of Allergin-1 to FcεRIs on mast cells may inhibit the signal transduction from FcεRIs to intracellular immunoreceptor tyrosine-based inhibitory motif (ITIM),generate ITIM inhibitory signals,which then participate in the regulation of mast cell degranulation,and finally block the initiation of allergic inflammation. 标签:His-tag |
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