蛋白质/抗原/多肽 >> 重组蛋白
重组16号染色体开放阅读框41蛋白
产品介绍 基因名： CHTF18 产品别名： C16orf41； C321D2.2； C321D2.3； C321D2.4； CHL12； Ctf18； RUVBL； CHTF18； chromosome transmission fidelity factor 18； chromosome transmission fidelity factor 18； chromosome transmission fidelity protein 18 homolog； CTF18, chromosome transmission fidelity factor 18 homolog； homolog of yeast CHL12； some homology with holliday junction DNA helicase RUVB like； 16号染色体开放阅读框41； 背景信息： CTF18 is a 975 amino acid protein encoded by the human gene CHTF18. CTF18 is a protein that is structurally related to the Rad24 and RFC (replication factor C) proteins. CTF18 is believed to form a novel RFC complex and functions redundantly with Rad24 in the DNA replication block checkpoint. The CTF18-RFC complex is a seven-subunit structure that consists of the four small subunits of RFC, together with CTF18, DCC1, and CTF8. This RFC complex is responsible for loading the replication clamp PCNA (Proliferating Cell Nuclear Antigen) onto DNA and functions in DNA replication and repair. Regulated unloading of PCNA during the progression and termination of DNA replication does not seem to be a function of the CTF18-RFC complex. 标签：His-tag |
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