蛋白质/抗原/多肽 >> 重组蛋白
重组中心体肌动蛋白γ1/增强型PI3K蛋白
产品介绍 基因名: Agap2 产品别名: Centg1; Pike; Agap2; ArfGAP with GTPase domain, ankyrin repeat and PH domain 2; ArfGAP with GTPase domain, ankyrin repeat and PH domain 2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2; AGAP-2; centaurin, gamma 1; cnt-g1; nuclear GTPase PIKE; phosphatidylinositol 3-kinase enhancer; 中心体肌动蛋白γ1/增强型PI3K蛋白; 背景信息: GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion. 标签:His-tag |
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