蛋白质/抗原/多肽 >> 重组蛋白
重组谷氨酸脱羧酶样蛋白1
产品介绍 基因名: Gadl1 产品别名: 1110027M19Rik; ADC; CSADC; Gadl1; glutamate decarboxylase-like 1; glutamate decarboxylase-like 1; acidic amino acid decarboxylase GADL1; aspartate 1-decarboxylase; cysteine sulfinic acid decarboxylase; glutamate decarboxylase-like protein 1; 谷氨酸脱羧酶样蛋白1; 谷氨酸脱羧酶样蛋白1(GADL1); 背景信息: There are two forms of glutamic acid decarboxylases (GADs) that exist in brain: GAD-65 (also known as GAD2) and GAD-67 (also known as GAD1, GAD or SCP). GAD-65 and GAD-67 are members of the group II decarboxylase family of proteins and are responsible for catalyzing the rate limiting step in the production of GABA (gamma-aminobutyric acid) from L-glutamic acid. Although both GADs are found in brain, GAD-65 localizes to synaptic vesicle membranes in nerve terminals, while GAD-67 is distributed throughout the cell. GAD-67 is responsible for the basal levels of GABA synthesis. In the case of a heightened demand for GABA in neurotransmission, GAD-65 transiently activates to assist in GABA production. As a member of the group II decarboxylase family, GADL1 (Glutamate decarboxylase-like protein 1) is a 521 amino acid protein that utilizes pyridoxal phosphate as a cofactor for its carboxylase activity. There are two isoforms of GADL1 that exist as a result of alternative splicing events. 标签:His-tag |
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