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蛋白质/抗原/多肽 >> 重组蛋白
重组早老素稳定因子样蛋白/γ分泌酶组件蛋白APH1
重组早老素稳定因子样蛋白/γ分泌酶组件蛋白APH1图片
交货期: 1周
索取资料及报价
交货期:1周
产品别名:Recombinant APH1B
Recombinant aph-1 homolog B, gamma-secretase subunit protein
产品介绍
基因名:

APH1B


产品别名:

APH-1B; PRO1328; PSFL; TAAV688; APH1B; aph-1 homolog B, gamma-secretase subunit; aph-1 homolog B, gamma-secretase subunit; gamma-secretase subunit APH-1B; APH1B gamma secretase subunit; anterior pharynx defective 1 homolog B; aph-1beta; 早老素稳定因子样蛋白/γ分泌酶组件蛋白APH1;


背景信息:
Anterior pharynx defective 1 (Aph-1) is a polytopic, seven-pass membrane protein that functions as one of the four essential components in the presenilin-Gamma-secretase enzyme complex. This enzyme complex is necessary for the intra-membrane proteolysis of several different membrane proteins, including the beta-Amyloid precursor protein, and is involved in multiple neurodevelopmental signaling pathways. Aph-1b and Aph-1a are splice variants of Aph-1. Aph-1b specifically lacks exon 4, which encodes for the entire fourth transmembrane domain, causing the protein to be destabilized. Deficiency of Aph-1a causes a reduction in Gamma-secretase activity, however deficiency of Aph-1b does not; thus, Aph-1b may execute redundant functions in the cell. Aph-1b expression and Gamma-secretase activity may be implicated in neurodevelopmental disorders, such as schizophrenia.

标签:His-tag   
分类:Recombinant  
类型:Protein   
偶联物:Unconjugated
内毒素水平:按批次,参阅瓶身标签
性状:Liquid
浓度:Batch dependent (Please refer to the vial label for the specific concentration.)
纯化类型:purified
内含物:不含防腐剂
应用:Positive Control;Immunogen;SDS-PAGE;WB.
储存:2-8°C不超过一个月,-80°C不超过12个月。避免反复冻融。
注意事项:仅供实验室使用。不适用于人类或动物的任何临床,治疗或诊断用途。不适合动物或人类食用。

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