蛋白质/抗原/多肽 >> 重组蛋白
重组候选肿瘤抑制基因MARVELD1蛋白
产品介绍 基因名: MARVELD1 产品别名: GB14; MARVD1; MRVLDC1; bA548K23.8; MARVELD1; MARVEL domain containing 1; MARVEL domain containing 1; MARVEL domain-containing protein 1; MARVEL (membrane-associating) domain containing 1; occludin; putative MARVEL domain-containing protein 1; 候选肿瘤抑制基因MARVELD1; 背景信息: MARVELD1, (MARVEL domain-containing 1), is one of the MARVEL (MAL and related proteins for vesicle trafficking and membrane link) domain-containing proteins. It is a nuclear-localized protein that is widely expressed in normal human tissues. While it has been reported to be overexpressed in colon cancer, MARVELD1 protein levels are generally lower in several primary tumors including ovary, breast, kidney, bladder and liver. This lower level of MARVELD1 expression in tumors is thought to be due to a higher methylation status of the MARVELD1 promoter as treatment of MDA-MB-361 with 5-aza-2'-deoxycytidine restores MARVELD1 expression, suggesting that loss of MARVELD1 expression may contribute to tumorgenicity. 标签:His-tag |
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