蛋白质/抗原/多肽 >> 重组蛋白
重组轴突生长诱向因子G2(NtnG2)蛋白
产品介绍 基因名: NTNG2 产品别名: LHLL9381; Lmnt2; NEDBASH; NTNG1; bA479K20.1; NTNG2; netrin G2; netrin G2; netrin-G2; laminet 2; netrin G1; 轴突生长诱向因子G2(NtnG2); 轴突生长诱向因子G2/神经突起生长导向因子G2; 背景信息: Netrin proteins are a family of laminin-related secreted proteins that provide guidance signals for axonal growth and cell migration during development. Netrin-1, which is the mammalian homolog of UNC-6 from C. elegans, is largely expressed in the developing nervous system and in mesodermal tissues. Netrin-1 is expressed by the floor plate as either a cell associated protein or in a diffusible form, and it binds to several surface receptor components, including deleted in colorectal cancer (DCC) and neogenin. During embryonic development, netrin-1 diffuses through the neuronal epithelium, where it forms a chemoattractant gradient that directs axonal migration to the ventral midline of the spinal cord. Netrin-2 and the corresponding mouse homolog netrin-3 are expressed primarily in the lower two-thirds of the spinal cord, and, like netrin-1, they can either attract or repel commissural axons at a distance. Netrin signaling is dependent on the concentration of calcium outside the cell and the level of PKA activity. In axonal cells, a reduction in PKA activity converts the responsiveness of the axons to the netrin proteins, as the cells are repelled, rather than attracted, by the netrin gradient. 标签:His-tag |
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