蛋白质/抗原/多肽 >> 重组蛋白
重组环指蛋白调节蛋白激酶C蛋白
产品介绍 基因名: TRIM41 产品别名: RINCK; TRIM41; tripartite motif containing 41; tripartite motif containing 41; E3 ubiquitin-protein ligase TRIM41; RING finger-interacting protein with C kinase; RING-finger protein that interacts with C kinase; RING-type E3 ubiquitin transferase TRIM41; 环指蛋白调节蛋白激酶C蛋白; 背景信息: Tripartite motif-containing protein 41 (TRIM41), also known as RINCK, is a 630 amino acid member of the TRIM family, also known as the RING-B-box coiled-coil (RBCC) family. Members of the RBCC family have an N-terminal RING finger, followed by one or two zinc-binding domains (B-box domains), a leucine coiled-coil region and a variable C-terminal domain. Localized to both the nucleus and cytoplasm, TRIM41 associates with protein kinase C (PKC) through the C1A domain of PKC. Studies have shown that overexpression of TRIM41 reduces the levels of PKC in cells, whereas knockdown of TRIM41 leads to increased levels of PKC. Thus, it is hypothesized that TRIM41 plays a role in regulating PCK levels in cells, specifically through the ubiquitination of PKC. Four isoforms of TRIM41 exist as a result of alternative splicing events. 标签:His-tag |
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