蛋白质/抗原/多肽 >> 重组蛋白
重组低密度脂蛋白受体5样蛋白
产品介绍 基因名: LRP5L 产品别名: LRP5L; LDL receptor related protein 5 like (pseudogene); LDL receptor related protein 5 like (pseudogene); LRP-5-like; low density lipoprotein receptor-related protein 5-like; low-density lipoprotein receptor-related protein 5-like protein; 低密度脂蛋白受体5样蛋白; 低密度脂蛋白受体相关蛋白5样蛋白(LRP5L); 背景信息: Members of the LDL receptor gene family, including LDLR (low density lipo-protein receptor), LRPs (low density lipoprotein related proteins), Megalin (also designated GP330), VLDLR (very low density lipoprotein receptor) and ApoER2, are characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. Of the known family members, LRP5 is most closely related to LRP1. However, LRP5 has a unique organization of EGF and LDLR repeats compared to other LDLR family members and likely represents a new category in this family. LRP is expressed in rat tibia, specifically in areas of the bone that are involved in remodeling. LRP5 is a Wnt coreceptor that binds to Axin and regulates the canonical Wnt signaling pathway. LRP5 affects bone mass accrual during growth. Mutations in LRP5 cause the autosomal recessive disorder osteoporosis-pseudoglioma syndrome (OPPG). LRP5L is a related protein that exists as two isoforms produced by alternative splicing. 标签:His-tag |
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