蛋白质/抗原/多肽 >> 重组蛋白
重组促性腺素释放激素受体2蛋白
产品介绍 基因名: GNRHR2 产品别名: GnRH-II-R; GNRHR2; gonadotropin releasing hormone receptor 2 (pseudogene); gonadotropin releasing hormone receptor 2 (pseudogene); GnRH receptor II 5TM; Type II GnRH receptor; gonadotropin-releasing hormone (type 2) receptor 2, pseudogene; 促性腺素释放激素受体2; 背景信息: Gonadotropin-releasing hormone (GnRH) is released in a pulsatile manner that varies with the reproductive cycle. This hypothalamic hormone is transported to the pituitary, where it binds to specific receptors and regulates the synthesis and release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Localized to the cell membrane, GnRHR2 mediates its own receptor activity via association with G proteins, thereby activating a phosphatidylinositol-calcium second messenger system that regulates GnRHR2 function. GnRHR2 is thought to have potent antiproliferative effects on ovarian and endometrial cancer cells, suggesting a possible role in tumor suppression. Due to alternative splicing events, GnRHR2 is expressed as two isoforms. 标签:His-tag |
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