蛋白质/抗原/多肽 >> 重组蛋白
重组G蛋白偶联受体TGR7蛋白
产品介绍 基因名: MRGPRD 产品别名: MRGD; TGR7; MRGPRD; MAS related GPR family member D; MAS related GPR family member D; mas-related G-protein coupled receptor member D; G-protein coupled receptor TGR7; MAS-related GPR, member D; beta-alanine receptor; mas-related G protein-coupled MRGD; G蛋白偶联受体TGR7蛋白; 背景信息: Mas-related G protein-coupled receptors are sensory neuron-specific G protein-coupled receptors that are usually involved in the development and function of nociceptive neurons and may also regulate the sensation or modulation of pain. MRGD (MAS-related GPR, member D), also known as MRGPRD or TGR7, is a 321 amino acid multi-pass membrane protein that belongs to the G-protein coupled receptor 1 family and the Mas subfamily. MRGD is suggested to function specifically as a receptor for beta-alanine, a naturally occurring beta amino acid. Beta-alanine induces Ca2+ influx and decreases forskolin-stimulated cAMP production in cells expressing MRGD. Neurons of outer epidermis that express MRGD act as nociceptors in which they respond indirectly to external stimuli by detecting ATP release in the skin. MRGD is encoded by a gene located on human chromosome 11q13.2. 标签:His-tag |
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