蛋白质/抗原/多肽 >> 重组蛋白
重组1号染色体开放阅读框216蛋白
产品介绍 基因名: C1orf216 产品别名: C1orf216; chromosome 1 open reading frame 216; chromosome 1 open reading frame 216; UPF0500 protein C1orf216; 1号染色体开放阅读框216; 背景信息: Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma. The C1orf216 gene product has been provisionally designated C1orf216 pending further characterization. 标签:His-tag |
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