蛋白质/抗原/多肽 >> 重组蛋白
重组α2-巨球蛋白样蛋白1(a2ML1)
产品介绍 基因名: A2ML1 产品别名: CPAMD9; OMS; p170; A2ML1; alpha-2-macroglobulin like 1; alpha-2-macroglobulin like 1; alpha-2-macroglobulin-like protein 1; C3 and PZP-like, alpha-2-macroglobulin domain containing 9; α2-巨球蛋白样蛋白1(a2ML1); α2巨球蛋白样蛋白1; 背景信息: alpha-2-Macroglobulin (alpha-2M) is a homotetrameric serum protein consisting of four identical subunits that form dimers through disulfide bonds. Initially, alpha-2M was characterized as a pan-proteinase inhibitor that was able to “bait” proteinases into cleaving specific peptide sequences on alpha-2M. This interaction induces a conformational change in alpha-2M, thus enabling it to “trap” the proteinase and further inhibit its activity. Subsequently, alpha-2M has been shown to function as a carrier protein and regulator of cytokines during inflammation. Circulating transforming growth factor beta (TGF beta) in serum is primarily bound to alpha-2M, which renders TGF∫ inactive. Mutations and deletions in the gene encoding alpha-2M are associated with an increased incidence of Alzheimer's Disease (AD). Alpha-2-macroglobulin-like protein 1 (alpha2ML1) is a related protein that is expressed in the epidermis and may play a role in keratinocyte differentiation. 标签:His-tag |
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