蛋白质/抗原/多肽 >> 重组蛋白
重组钾通道四聚体结构域蛋白11
产品介绍 基因名: KCTD11 产品别名: C17orf36; KCASH1; REN; REN/KCTD11; KCTD11; potassium channel tetramerization domain containing 11; potassium channel tetramerization domain containing 11; BTB/POZ domain-containing protein KCTD11; RING-type E3 ubiquitin transferase subunit KCTD11; potassium channel tetramerization domain-containing protein 11; retinoic acid, EGF, NGF induced gene protein; 钾通道四聚体结构域蛋白11; 背景信息: The KCTD11 gene encodes a protein that has been identified as a suppressor of Hedgehog signaling. Its inactivation might lead to a deregulation of the tumor promoting Hedgehog pathway in medulloblastoma. Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcrition factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state. 标签:His-tag |
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