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蛋白质/抗原/多肽 >> 重组蛋白
重组钾通道四聚体结构域蛋白11
重组钾通道四聚体结构域蛋白11图片
交货期: 1周
索取资料及报价
交货期:1周
产品别名:Recombinant KCTD11
Recombinant potassium channel tetramerization domain containing 11 protein
产品介绍
基因名:

KCTD11


产品别名:

C17orf36; KCASH1; REN; REN/KCTD11; KCTD11; potassium channel tetramerization domain containing 11; potassium channel tetramerization domain containing 11; BTB/POZ domain-containing protein KCTD11; RING-type E3 ubiquitin transferase subunit KCTD11; potassium channel tetramerization domain-containing protein 11; retinoic acid, EGF, NGF induced gene protein; 钾通道四聚体结构域蛋白11;


背景信息:
The KCTD11 gene encodes a protein that has been identified as a suppressor of Hedgehog signaling. Its inactivation might lead to a deregulation of the tumor promoting Hedgehog pathway in medulloblastoma. Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcrition factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state.

标签:His-tag   
分类:Recombinant  
类型:Protein   
偶联物:Unconjugated
内毒素水平:按批次,参阅瓶身标签
性状:Liquid
浓度:Batch dependent (Please refer to the vial label for the specific concentration.)
纯化类型:purified
内含物:不含防腐剂
应用:Positive Control;Immunogen;SDS-PAGE;WB.
储存:2-8°C不超过一个月,-80°C不超过12个月。避免反复冻融。
注意事项:仅供实验室使用。不适用于人类或动物的任何临床,治疗或诊断用途。不适合动物或人类食用。

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