蛋白质/抗原/多肽 >> 重组蛋白
重组1号染色体开放阅读框55蛋白
产品介绍 基因名: SDE2 产品别名: C1orf55; dJ671D7.1; SDE2; SDE2 telomere maintenance homolog; SDE2 telomere maintenance homolog; replication stress response regulator SDE2; UPF0667 protein C1orf55; protein SDE2 homolog; 1号染色体开放阅读框55; 背景信息: Belonging to the UPF0667 family, C1orf55 is a 451 amino acid protein that is phosphorylated upon DNA damage, likely by Atm or ATR. There are three different isoforms of C1orf55 that are produced as a result of alternative splicing events. The gene encoding C1orf55 maps to human chromosome 1, the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. 标签:His-tag |
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