蛋白质/抗原/多肽 >> 重组蛋白
重组FBXW12蛋白
产品介绍 基因名: FBXW12 产品别名: FBW12; FBXO12; FBXO35; FBXW12; F-box and WD repeat domain containing 12; F-box and WD repeat domain containing 12; F-box/WD repeat-containing protein 12; F-box and WD-40 domain protein 12; F-box and WD-40 domain-containing protein 12; F-box only protein 35; F-box- and WD40-repeat-containing protein; FBXW12蛋白; 背景信息: Belonging to the F-box family of proteins, FBXO35 (F-box only protein 35), also designated F-box and WD-40 domain-containing protein 12 (FBXW12 or FBXO12), is a 464 amino acid protein that contains one C-terminal F-box domain. F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein)-type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. They are members of a larger family of proteins that are involved in the regulation of a wide variety of cellular mechanisms, including the cell cycle, the immune response, signaling cascades and developmental processes. They function by targeting proteins, such as cyclins, cyclin-dependent kinase inhibitors, I˚B-å and ∫-catenin, for degradation by the proteasome after ubiquitination. Via its F-box domain, FBXO35 can directly interact with Skp1 p19 and CUL-1. FBXO35 is ubiquitously expressed at low levels in most human tissues. 标签:His-tag |
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