紧密连接蛋白18重组兔单抗

商品属性

产品介绍
英文名称Claudin 18.2 Recombinant Rabbit mAb

中文名称紧密连接蛋白18重组兔单抗

别    名CLD18_HUMAN; Claudin-18; Claudin18; CLDN18; UNQ778/PRO1572; SFTA5; SFTPJ; CLDN18.2; Claudin-18.2; Claudin18.2;  

研究领域细胞生物  信号转导  转运蛋白  细胞粘附分子  内皮细胞  跨膜蛋白  

抗体来源Rabbit

克隆类型Recombinant

克 隆 号R7G12

交叉反应Human,Mouse,Rat

产品应用IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

理论分子量28 kDa

检测分子量

细胞定位细胞膜

性    状Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human Claudin-18.2

亚    型IgG

纯化方法affinity purified by Protein A

缓 冲 液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

PubMedPubMed

产品介绍The Claudin superfamily consists of many structurally related proteins in humans (1). These proteins are important structural and functional components of tight junctions in paracellular transport (1,2). Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues (1). Three classes of proteins are known to localize to tight junctions, including the Claudins, Occludin and Junction adhesion molecule (3). Claudins, which consist of four transmembrane domains and two extracellular loops make up tight junction strands (4). Emerging evidence suggests that the Claudin family of proteins regulates transport through tight junctions via differential discrimination for solute size and charge (5).Claudin expression is often highly restricted to specfic regions of different tissues and may have an important role in transcellular transport through tight junctions (6).

产品应用范围

免疫检测技术：Western Blot（WB, 1:100-500）、ELISA（1:500-1000）、免疫组化（IHC, 1:100-500）、流式细胞术（Flow-Cyt, 1:20-100）、免疫沉淀（IP, 1:20-100）等。

适用样本：石蜡切片（需抗原修复）、细胞提取液、重组蛋白等。

服务与定制

抗原制备：支持天然蛋白、重组蛋白、多肽、小分子半抗原（需偶联载体蛋白）等定制服务。

抗体开发：可根据客户提供的基因序列（GeneID）、氨基酸序列等信息设计合成抗原并制备抗体。

附加服务：抗体标记、试剂盒开发、免疫学检测方案优化等。

使用注意事项

**使用前建议进行预实验以确定**稀释比例。

冻干粉需用无菌PBS或超纯水复溶，液体抗体避免剧烈震荡。

长期保存建议分装，避免反复冻融导致效价降低。

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