商品属性

产品介绍The cerebral and vascular plaques associated with Alzheimer's disease are mainly composed of Amyloid beta peptides. beta Amyloid is derived from cleavage of the Amyloid precursor protein and varies in length from 39 to 43 amino acids. beta Amyloid [1-40], beta Amyloid [1-42], and beta Amyloid [1-43] peptides result from cleavage of Amyloid precursor protein after residues 40, 42, and 43, respectively. The cleavage takes place by gamma-secretase during the last Amyloid precursor protein processing step. beta Amyloid [1-40], beta Amyloid [1-42], and beta Amyloid [1-43] peptides are major constituents of the plaques and tangles that occur in Alzheimer's disease. beta Amyloid antibodies and peptides have been developed as tools for elucidating the biology of Alzheimer's disease.

商品详情

英文名称beta-Amyloid(1-42) Mouse mAb

中文名称β淀粉样肽（1-42）单克隆抗体

别    名beta-Amyloid(1-42); A4; AAA; ABETA; ABPP; AD1; Alzheimers Disease Amyloid Protein; Amyloid B; Amyloid beta A4 Protein Precursor; Amyloid beta; Amyloid of Aging and Alzheimer Disease; APP; APPI; B Amyloid; beta APP; Cerebral Vascular Amyloid Peptide; CTFgamma; CVAP; PN II; PN2; PreA4; Protease nexin II; A beta; Amyloid 1-42.  

研究领域细胞生物  免疫学  神经生物学  Alzheimer's  

抗体来源Mouse

克隆类型Monoclonal

克 隆 号6C8

交叉反应Human (predicted: Mouse,Rat)

产品应用WB=1:500-2000,IHC-P=1:500-5000,IHC-F=1:500-5000,IF=1:200-5000

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

理论分子量4.4 kDa

检测分子量

细胞定位细胞核 细胞浆 细胞膜 细胞外基质

性    状Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human beta-Amyloid(1-42): 672-713/770 or 1-42/42

亚    型IgG2b

纯化方法affinity purified by Protein A

缓 冲 液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

PubMedPubMed

产品特性

交叉反应性：

标准抗体：人（Human）、小鼠（Mouse）、大鼠（Rat）、狗（Dog）、猪（Pig）。

磷酸化抗体：特异性识别Ser774位点磷酸化的动力蛋白1。

分子量：预测约97kDa（非磷酸化形式）。

免疫原：

磷酸化抗体：合成的人源动力蛋白1磷酸化肽段（Ser774附近）。

纯化方式：Protein A亲和纯化。

保存条件：

含15mM叠氮化钠防腐剂，1% BSA，0.01M PBS（pH 7.4），建议分装后-20℃保存。

实验应用

适用方法：

蛋白质印迹（WB）：1:100–500

酶联免疫吸附试验（ELISA）：1:500–1000

免疫组化（IHC-P/F）：1:100–500（石蜡切片需抗原修复）

免疫荧光（IF/ICC）：1:100–500

注意事项：磷酸化抗体尚未验证其他应用场景。

主要用途

仅供科研实验使用，不可用于诊断或治疗。

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