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UNC 0631

品牌
J&K
CAS
1320288-19-4
货号
1578395
规格纯度
98%, 是G9a抑制剂, IC50为4nM
参考价格
1017 *本价格含增值税费
促销
服务
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  • 增值税票
数量
-+
产品名称:
1320288-19-4
UNC 0631
产品介绍:

基本信息

分子式C37H61N7O2
分子量635.93
存储条件Freezer -20℃

产品描述

UNC 0631 is a potent G9a inhibitor with IC50 value of 4 nM. IC50 value: 4 nM [1] Target: G9a UNC 0631, which had high in vitro potency versus G9a and improved lipophilicity, was highly potent (IC50 < 0.06 μM) in reducing H3K9me2 levels in MDA-MB-231 cells and had low cell toxicity. In particular, compounds 7 was more potent than compound 5 and had a similar tox/function ratio in MDAMB-231 cells. UNC 0631 showed excellent separation of functional potency versus cell toxicity in MDA-MB-231 cells, thecompound was further evaluated in a variety of cell lines to characterize it's cellular potency and cell toxicity. UNC 0631 had excellent tox/function ratios in these cell lines.

靶点(IC50 & Targe)

G9a

参考文献

[1]. Liu F, et al. Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines. J Med Chem. 2011 Sep 8;54(17):6139-50.

安全信息

图形或危害标志
提示语Warning
危险说明H302
H410
防范说明P264
P270
P273
P301+P312
P330
P391
P501
UN号码3077
危险分类9
包装等级III

百灵威科技

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