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Evatanepag(CP-533536)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Evatanepag(CP-533536)图片
CAS NO:223488-57-1
规格:≥98%
包装与价格:
包装价格(元)
2mg电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
Evatanepag (formerly known as CP-533536; CP-533536 free acid) is a novel, potent and selective agonist of EP2 receptor prostaglandin E2 (PGE2). It induces local bone formation with EC50 of 0.3 nM. CP-533536 demonstrates the ability to heal fractures when administered locally as a single dose in rat models of fracture healing. CP-533536 demonstrates excellent in vitro potency against EP2 and selectivity against a broad panel of other targets.
理化性质和储存条件
Molecular Weight (MW) 468.57
Formula C25H28N2O5S
CAS No. 223488-57-1
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: ≥ 32 mg/mL
Water: N/A
Ethanol: N/A
SMILES Code O=C(O)COC1=CC=CC(CN(CC2=CC=C(C(C)(C)C)C=C2)S(=O)(C3=CC=CN=C3)=O)=C1
Synonym

Evatanepag; CP-533536; CP 533536; CP533536;

Chemical Name: 2-(3-((N-(4-(tert-butyl)benzyl)pyridine-3-sulfonamido)methyl)phenoxy)acetic acid

实验参考方法
In Vitro

In vitro activity: Evatanepag (formerly known as CP-533536) is a potent and selective agonist of EP2 receptor prostaglandin E2 (PGE2). It induces local bone formation with EC50 of 0.3 nM. C


Kinase Assay: Evatanepag (CP-533536) is an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation with EC50 of 0.3 nM. CP-533536 is a potent and selective EP2agonist. CP-533536 demonstrates the ability to heal fractures when administered locally as a single dose in rat models of fracture healing. CP-533536 demonstrates excellent in vitro potency against EP2 and selectivity against a broad panel of other targets.

In Vivo P-533536 demonstrates the ability to heal fractures when administered locally as a single dose in rat models of fracture healing. CP-533536 demonstrates excellent in vitro potency against EP2 and selectivity against a broad panel of other targets.
Animal model Rats
Formulation & Dosage Administered locally as a single dose
References Bioorg Med Chem Lett. 2009 Apr 1;19(7):2075-8.