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PTP1B-IN-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PTP1B-IN-1图片
CAS NO:612530-44-6
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议

产品介绍
理化性质和储存条件
Molecular Weight (MW) 212.23
Formula C8H8N2O3S
CAS No. 612530-44-6
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: ≥ 38 mg/mL
Water: <1 mg/mL
Ethanol:
SMILES Code O=C(CN1C2=CC=CC=C2)NS1(=O)=O
Synonyms PTP1B inhibitor 1; PTP1B-inhibitor-1; PTP1B-IN-1; PTP1B IN 1; PTP1BIN1
实验参考方法
In Vitro

In vitro activity: PTP1B-IN-1 is a potent and new class of inhibitor of protein tyrosine phosphatase-1B (PTP1B) with IC50 of 1.6 mM; It incorporates the 1,2,5-thiadiazolidin-3-one-1,1-dioxide template that was identified through structure-based design. The site specific functionalization of phosphate groups with amino acid side chains of substrate proteins represents one of the most important regulatory mechanisms of biological systems. Phosphorylation and dephosphorylation are reversibly catalyzed by protein kinases and protein phosphatases, and the aberrant regulation of these enzymes is associated with the onset and progression of various disease states such as cancer, diabetes, neurodegenerative and autoimmune disorders, making these proteins attractive targets for drug discovery.


Kinase Assay: PTP1B-IN-1 is a potent and new class of inhibitor of protein tyrosine phosphatase-1B (PTP1B) with IC50 of 1.6 mM;


Cell Assay:

In Vivo
Animal model
Formulation & Dosage
References Bioorg Med Chem Lett. 2005 May 16;15(10):2503-7; Bioorg Med Chem. 2011 Apr 1;19(7):2145-55.